Dr. Steven Stodghill of the Department of Pharmaceutical, Social & Administrative Sciences and his team have had three abstracts accepted for the American Association of Pharmaceutical Sciences annual meeting in November.
- Development of a Sustained-Release Donepezil Hydrochloride Formulation by Hot Melt Extrusion This study demonstrates the sustained release of highly water-soluble drugs such as donepezil hydrochloride can be formulated by continuous processing using twin-screw extrusion employing Compritol® 888 ATO as a hydrophobic matrix.
- Effect of polymer molecular weight on Hot Melt Extrusion processing and dissolution of Clotrimazole The objective of this study was to evaluate the effect of different Polyvinylpyrrolidone (PVP) molecular weights on the extrudability and dissolution of clotrimazole by hot melt extrusion techniques. PVPs polymers are water-soluble and used routinely as a carrier to enhance the solubility for an API. Two different drug loads were used to investigate their effects.
- Application of Solid Crystal Suspensions using Hot Melt Extrusion for Enhancement of Solubility and Stability of Efavirenz The formulation of crystal suspensions by Hot Melt Extrusion significantly increased the solubility and stability of Efavirenz. This technique/process provided an alternative approach for enhancing solubility of poorly water-soluble compounds using xylitol as a primary matrix carrier.